BACKGROUND AND OBJECTIVE: LAPAROSCOPIC CHOLECYSTECTOMY (LC) is now used in the management of acute cholecystitis. The aim of this study was to evaluate the role of LC for acute cholecystitis (AC) and compare it with acute open CHOLECYSTECTOMY (OC) and elective LAPAROSCOPIC CHOLECYSTECTOMY (ELC) in terms of complications, conversion rate, and hospital stay and operation time.METHODS: This clinical study was carried out 01) 235 patients. Ninety-four patients with AC were admitted to emergency department. They were randomly divided into acute LAPAROSCOPIC CHOLECYSTECTOMY (ALC) (n=46) and OC(n=48). One hundred and forty one patients with symptomatic gallstone underwent ELC.FINDINGS: The median of total stay was 5, 3 and 2 days (mean±SD 5.39±2.9, 3.39±3.14 and 1.99±1.3 days) in OC, ALC and ELC, respectively (p=0.005). The mean duration of operation time was 53.2±3.2, 58.8±29.3 and 39.9±18.8 minutes in OC, ALC and ELC, respectively (p=0.005). Major complications occurred in 5 patients (10.4%) with ac, 2 patients (5.1%) with ALC and 5 patients (3.6%) with ELC. CONCLUSION: The results of this study showed that in patients with ALC in comparison to OC, there are a decrease in total hospital stay, post operative hospital stay and major complications. LC should be considered as a first choice before open surgery.